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Professor Marie Katherine Wiseman is a museum scientist in the TV series of Curious George. She works in both research and administrative capacities. Her intelligent colleagues include Professor Einstein and Professor Anthony Pizza. Prof. Wiseman is a motherly figure to George and a close friend with the Man.
- She's a workaholic.
- She learned how to run when Pizza and Einstein forced her to run a race or else they wouldn't sponsor it.
- George was her running mentor.
- She took George to a dog show.
- Chef Pisghetti and Netti taught her how to cook.
- Before learning how to properly cook, her cake glued George's mouth shut, only to be "revived" by Betsy.
- The Man gave her a CD for her birthday; George gave her a peeled clemantine glued to a banana peel.
- She taught George how to make a metal detector from a calculator a radio and tape.
- She knows when George is down or sad from his tone of monkey sounds.
- The Man often works with her when there's a crisis at the museum.
- She is the Man's possible close friend crush.