George's human owner is Ted Shackleford (The Man with the Yellow Hat), who tries to pay close attention to George, but mostly always loses concentration. George is generally a curious normal and adorable little monkey, but not normal when he gets up to things. George is always asking questions to Ted and his other friends.
George previously lived in Africa with his animal friends, until he followed The Man With The Yellow Hat (which was Ted) to New York City and Chicago (where it was going to be his new home) in the first film.
George is always very curious about many things (as implied by his name), a trait, which helps George learn, but also often lands him in trouble, but soon in the future, will learn better and act well-behaved like his siblings. George has an impressive proficiency in visual art (as well as a strong sense of natural beauty).
George is used as the teachable character in the series, and he is the one to whom new concepts are explained in detail by the other characters; the viewers learn the new concept along with George.
Throughout the series, George's adventures continue to evolve, as when he flew a kite to getting a kite string back (in Curious George Flies a Kite).
A lot of times, George will have different outfits, or clothing based on the occasion, or event. In many episodes, he has a red cap. In the fall & winter, he has a red coat & winter hat.
He is ambidextrous, sometimes writing and doing dominant-hand activities with his left hand and sometimes with his right throughout the series and even using his feet.
George is ambidextrous, he uses both hands to write and draw.
The trophy he wins in the episode "Bag Monkey" is not on the same shelf as The Man with the Yellow Hat's trophies. It is in his closet with a purple octopus toy inside it where he had already organized.
Many people remember George having a tail and some even remember him using his tail for things (Ex. Swinging on something). This is an example of the Mandela Effect.