Cross was born in Atlanta, Georgia on April 4, 1964, the son of Barry and Susi, the former of whom emigrated from Leeds, England. Six months after his birth, Cross' family moved to Florida. After additional moves to New York and Connecticut, the family settled back in Roswell, Georgia, where Cross remained for nearly a decade. His family was poor and Barry left the family when Cross was 10 years old; the two have not spoken since he was 19, though they both primarily resided in New York City until Cross sold his home there in 2011. Cross and his family were evicted from their home while living in Georgia. He spent some time living in motels and at friends' homes while growing up. He has two sisters and once bailed his youngest sibling out of jail. In 1990, a new comedy scene began to emerge at the famous comedy club chain called Catch a Rising Star (where many of the comedians of the 1970s and 1980s got their start). Alongside Janeane Garofalo, Louis C.K., and other comics, Cross appeared regularly several nights a week. Cross formed the sketch comedy group "Cross Comedy" with 12 other performers, and they put on a new show every week. They were known for playing tricks on the audience, such as introducing fake comics or planting fake hecklers. Cross became increasingly focused on his comedy work. Cross performed at the alternative comedy club Un-Cabaret in Los Angeles. David Cross performed the voice of Junior in Curious George.